Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+, a compound that plays a crucial role in energy production, metabolism, and gene expression in the body. When we boost NMN levels in the body, we can enhance the biosynthesis of NAD+ and alleviate symptoms associated with depletion of this crucial nutrient.
NMN Plus Sustained Release is designed to slow and prolong NMN absorption, allowing a longer steady blood level concentration of the active ingredient. This enables NMN Plus Sustained Release to be given at higher doses less frequently.
NMN is an entirely natural compound found in our bodies. Various food sources also contain this compound in minuscule amounts. Edamame which has one of the higher contents, only show less than 1.9mg/100g. NMN is a direct and potent NAD+ supplement. Mice given an oral supplement of NMN showed increased liver NAD+ levels in just 10 minutes and showed an increase in muscle tissue by 30 minutes.
Increased NAD+ levels stimulate energy metabolism, DNA repair, and SIRTUIN activity. SIRTUINS are the longevity-genes shown to be active during caloric restriction and life-extension in many animal models.
THE SCIENCE
Scientists have now confirmed a direct link between falling NAD+ levels and aging in both animals and human subjects. A breakthrough study published by Harvard scientists in 2013 showed for the first time that some aspects of aging might be reversible. After treating old mice with NMN, several biometric markers that were subsequently measured resembled those of young mice: "the equivalent of a 60-year old converting to a 20-year old". The research and understanding into NAD+ metabolomics are ongoing, but what the science has highlighted thus far, is the importance of supporting and maintaining our NAD+ levels.
A long-term evaluation of oral supplementation of NMN in mice was found to be effective at improving NAD+ levels safely. Mice supplemented with NMN vs. a control group showed notable age-associated differences in mass, energy metabolism, blood sugar, lipid metabolism, gene expression changes, mitochondrial oxygen use, eye function, bone density and immune function with no apparent toxic effects.
NAD+ In the News
7-16-2016 Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
3-22-2018 - REWINDING THE CLOCK
NEW TIME MAGAZINE ARTICLE 3-22-18
Read the TIME MAGAZINE article Scientist Can Reverse Aging in Mice
References
A New-and Reversible-Cause of Aging - Harvard Medical School
Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats.